Synergistic effect of combined IFN-alpha2b and IFN-gamma treatment for periocular basal cell carcinoma

Efficacy of excisional surgery, curettage and combined curettage and electrodessication in treatment of basal cell carcinoma

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Vismodegib for periocular and orbital basal cell carcinoma.

IMPORTANCE Basal cell carcinoma (BCC) represents 90% of malignant eyelid tumors and is locally invasive and destructive, if left untreated. OBJECTIVE To assess the feasibility of using vismodegib for periocular and orbital BCC based on its efficacy and tolerability. DESIGN, SETTING, AND PARTICIPANTS In this prospective observational case series, consecutive patients with periocular or orbit...

IFN-gamma During Hepatic Stellate Cell Activation

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IFN-gamma, IGIF, and IDDM.

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.

We generated a mouse model with a 162 nt AU-rich element (ARE) region deletion in the 3' untranslated region (3'UTR) of the interferon-gamma (IFN-γ) gene that results in chronic circulating serum IFN-γ levels. Mice homozygous for the ARE deletion (ARE-Del) (-/-) present both serologic and cellular abnormalities typical of patients with systemic lupus erythematosus (SLE). ARE-Del(-/-) mice displ...